Expertise DescriptionI have more than 10 years experience in the areas of pharmacokinetics, neuropharmacology, drug-drug interactions, adverse drug effects, and drug delivery to the brain. This expertise encompasses pharmacology of both prescription drugs and drugs of abuse. I obtained my bachelor's of science degree in Pharmacology and my doctoral degree in Pharmaceutical Sciences, both from the University of Toronto, Canada. I then undertook postdoctoral training with a specific focus on neuropharmacology including drug uptake and effectiveness in the brain in both health and disease. I have worked as an Associate Professor in the Department of Pharmacology at the University of Arizona College of Medicine. My laboratory is funded by grants from the National Institutes of Health and the Arizona Biomedical Research Commission to undertake studies aimed at understanding changes in pharmacokinetics and drug response due to pathologies such as ischemic stroke, cerebral hypoxia, and acute/chronic pain. In addition to research, I teach principles of clinical pharmacology to medical students and molecular pharmacology to graduate students. I have over 5 years experience as a pharmacology expert witness with deposition, consultations, and courtroom testimony.
Areas of Expertise
My expert witness experience includes criminal and civil cases in which I have worked with both plaintiff counsel and attorneys representing the defendant. I have worked as a state expert in a DUI case that required a detailed explanation of central nervous system effects of multiple prescription and non-prescription drugs. I have also represented a defendant in a state DUI case, which required disentangling effects of prescription drugs and alcohol and explaining how pharmacological tolerance can modify the effects of centrally acting drugs. In civil matters, I have been retained as both a plaintiff expert and as a defense expert. Examples of civil matters that I have been involved with include: i) medical malpractice lawsuits involving excessive prescribing of centrally acting drugs including opioids; ii) a case that required an explanation of pharmacological effects of analgesic drugs and how such effects can lead to long-term health problems; iii) a case that required provision of an understandable explanation of how an analgesic drug can cause adverse drug effects including peripheral nerve injury; and iv) a matter in which the attorney required a pharmacology expert to determine whether prescription drugs were capable of causing death. Additionally, I have recently worked as a pharmacology expert in a large class action lawsuit involving a well-known energy drink product.
My consulting experience includes working with a pharmaceutical company on development of novel drugs to treat pseudobulbar affect (PBA), a neurological condition that results in exaggerated emotional responses such as laughing and/or crying. PBA is commonly observed in patients suffering from amyotrophic lateral sclerosis (ALS). As a pharmacology consultant, I worked with industrial pharmacologists to develop an experimental strategy to study CNS penetration of lead compounds designed by the company to treat PBA.
My professional experience includes having published over 30 peer-reviewed research and review articles and 5 book chapters in the field of CNS pharmacology. I have previously received the New Investigator Grant in Pharmacokinetics, Pharmacodynamics, and Drug Metabolism from the American Association of Pharmaceutical Scientists (AAPS) in 2011 and a Young Investigator Award from the International Society of Cerebral Blood Flow and Metabolism in 2013. In addition to research, I have experience teaching principles of clinical pharmacology to medical students and molecular pharmacology to graduate students at the University of Arizona College of Medicine. I have also been the chair of the Drug Transport Focus Group and eLearning Committee of the American Association of Pharmaceutical Scientists. I was elected to both positions by my peers based upon my achievements in research and my passion for teaching pharmacology.
|Ph.D.||University of Toronto|
|B.S.||University of Toronto|
Awards & Affiliation
* New Investigator Grant in Pharmacokinetics, Pharmacodynamics, and Drug Metabolism (awarded by American Association of Pharmaceutical Scientists in 2011)
* Young Investigator Award (awarded by International Society for Cerebral Blood Flow and Metabolism in 2013)
* Pharmacokinetics, Pharmacodynamics, and Drug Metabolism (PPDM) Section Service Award (awarded by the American Association of Pharmaceutical Scientists in 2016).
* Member, American Association of Pharmaceutical Scientists
* Member, American Society of Pharmacology and Experimental Therapeutics
American Association of Pharmaceutical Scientists (AAPS)